Title: Socioeconomic deprivation and differential associations with molecular subtypes of breast cancer: A global perspective

Date: 18 June 2024

Time: 1 - 2pm, tea and coffee will be served from 12.30pm

Presenter: Dr Jonine Figueroa

Venue: Yudowitz Lecture Theatre, Wolfsom Medical School, University Avenure, G12 8TT.  If you cannot attend in person please use this livestream link https://echo360.org.uk/section/19c1deaf-98c4-42a7-b0a3-33509b5f323d/public

Abstract: 

The etiology of cancer varies by tumour defined molecular subtypes, yet few studies evaluating socioeconomic factors have determined if differences exist in associations by tumour subtypes. Cancer disparities reflect the interplay of biological, environmental, and socioeconomic determinants. In the United States, disentangling racial and ethnic disparities in breast cancer (BC) including the effects of health care access and socioeconomic deprivation a challenge given they are highly correlated with race and ethnicity. We have leveraged Scottish Morbidity Records datasets on over 60,000 breast cancer (BC) diagnosed between 2000 and 2016 to determine the association of the Scottish Index of Multiple Deprivation (SIMD) with BC incidence and survival. Molecular subtypes of breast cancer were derived using tumor estrogen receptor (ER) status collected since 1997 and Progesterone Receptor and HER2 in 2009. For  ipsilateral breast recurrence (IBR) outcomes, we used a subset of data for BC diagnosed 2007-2008 and where manual case-note review for 3495 patients from 10 years post-diagnosis. I will show that SIMD has differential associations with different outcomes by molecular subtypes. I will also discuss ongoing extensions of this work in the United States using the Surveillance, Epidemiology and End Results (SEER) Cancer Registry Database and efforts to address cancer inequities through the G7 Cancer initiative.

Bio:

Dr. Jonine Figueroa is an internationally recognized expert in breast cancer epidemiology. As a leader of integrative molecular epidemiologic research with a focus on global health, she investigates risk factors associated with breast cancer incidence and mortality in diverse populations. To improve outcomes and address cancer inequities, Dr. Figueroa’s research aims to understand the interplay of biological, environmental, and socioeconomic determinants in cancer epidemiology studies.

Dr. Figueroa received a B.S. in genetics and developmental biology from the Pennsylvania State University, State College, a Ph.D. in molecular genetics and microbiology from Stony Brook University, and an M.P.H. from Columbia University, both in New York. Most recently, Dr. Figueroa was tenured Professor and Chair of Molecular Epidemiology and Global Cancer Prevention at the University of Edinburgh, United Kingdom, where she is an Honorary Fellow. She completed her postdoctoral training in US NIH Division of Cancer Epidemiology & Genetics (DCEG) as an NCI Cancer Prevention Fellow and was promoted to a tenure-track investigator position before leaving for the United Kingdom. Dr. Figueroa is the first researcher selected through the DCEG pilot of the Multi-Principal Investigator Search. She has also been selected for the NIH Distinguished Scholars Program.

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